This Notice alerts the extramural research community of two important updates related to application submission policies.
- Effective immediately NIH will no longer request or accept Letters of Intent (LOIs) as part of the application process.
- Effective immediately, NIH will no longer require applicants requesting $500,000 or more in direct costs (excluding consortium F&A costs) in any one budget period to contact the funding Institute or Center (IC) before application submission. All active NOFOs containing this requirement are superseded by this Notice and will be updated going forward.
Full Notice
National Institutes of Health
NOT-OD-26-019
December 3, 2025
